A new approach for detecting adventitious viruses shows Sf-rhabdovirus-negative Sf-RVN cells are suitable for safe biologicals production
Abstract Background Adventitious viral contamination in cell substrates used for biologicals production is a major safety concern.A powerful new approach that can be used to identify adventitious viruses is a combination of bioinformatics tools with massively parallel sequencing technology.Typically, this involves mapping or BLASTN searching indivi